ARTIFASCIA® IS AN INNOVATIVE DURAL REPAIR GRAFT TO ENHANCE PATIENT’S RECOVERY AFTER NEUROSURGERIES
Today, neurosurgeons often use a graft and a liquid sealant to repair the Dura and prevent cerebral-spinal fluid (CSF) leakage after neurosurgeries. Despite this, there still up to 30% chance of leakage after surgery. CSF leakage is highly dangerous to the patient and can result in long hospitalization and even a repeated surgery.
Nurami Medical’s ArtiFascia® for dural repair is a porous nanofiber graft made of medical grade synthetic polymers that addresses this problem. The graft incorporates biodegradable nanofibers, to boost dural regeneration, and a novel, temperature-sensitive viscoelastic sealant to prevent cerebral-spinal fluid (CSF) leakage. The use of ArtiFascia will eliminate the need to use a liquid sealant in addition to the graft, significantly reduce the chance of CSF leakage and enhance patient’s healing and recovery after neurosurgery.
ArtiFasica® is under clinical investigation and was implanted in over 12 patients.
ArtiFascia’s® thickness is comparable to human dura, and it is applied via a routine procedure. ArtiFascia’s® mechanical strength and flexibility enables for robust suturing, convenient handling and pliability that allows the device to conform to the surface of the dural defect without dangerous adhesions while maintaining a mechanical barrier against leakage. The patch degrades naturally over time, and is replaced by the native tissue with complete dural closure.
Nurami Medical’s ArtiFascia® is the first multifunctional nanofiber-based tissue reconstruction patch that combines two functions in a single device
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The porous nanofiber patch mimics natural extracellular matrices, providing a scaffold, which enables infiltration of fibroblasts and cells from the intact tissue, enhancing tissue regeneration, ultimately replacing damaged dural tissue.
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The temperature-sensitive and visco-elastic sealant becomes a deformable gel that penetrates suture holes and conforms to fibers, even when stretched. This novel gel eliminates the need for surgical sealants, ensuring watertight sealing of the site, reducing CSF leakage and potentially life-entry of threatening pathogens.
1
The porous nanofiber patch mimics natural extracellular matrices, providing a scaffold, which enables infiltration of fibroblasts and cells from the intact tissue, enhancing tissue regeneration, ultimately replacing damaged dural tissue.
2
The temperature-sensitive and visco-elastic sealant becomes a deformable gel that penetrates suture holes and conforms to fibers, even when stretched. This novel gel eliminates the need for surgical sealants, ensuring watertight sealing of the site, reducing CSF leakage, and potentially life-threatening pathogen entry.
In-vivo testing of ArtiFasciaTM has validated its supremacy over the state of the art, in terms of preventing leakage, mechanical strength, regeneration capabilities, tissue integration, suture retention and more.
Nurami Medical Nanofiber Technology © Copyright 2019
Designed & Created by Chen Ayala
Serves as Chairman of the of Department of
Neurosurgery at the Hannover Medical University Hospital, and Head of the
Commission for Technical Standards of the German Society of Neurosurgery, Secretary
of the European Society of Functional and Stereotactic Neurosurgery, and as Vice-
President of the World Society of Functional and Stereotactic Neurosurgery.
Agnesa Sharaev has 10 years’ experience in process development engineering and
production management in the biotechnology field. Among her expertise are development of
bio-material scaffolds for tissue engineering, leading engineering processes such as
scaling-up and technology transfer.. Agnesa is responsible for process development and
production management. Agnesa holds a B.Sc in Biotechnology Engineering from the Ort-
Braude college and certified as Quality Engineer from the Technion.